Rheuma Tv 
The long-term extension trial, contRAst X, published in BMJ Open, showed promising results regarding the safety and efficacy of otilimab, an anti-GM-CSF monoclonal antibody, in patients with rheumatoid arthritis (RA). This phase 3 multicenter study followed patients who had completed the contRAst 1-3 trials, assessing the effects of prolonged otilimab therapy. Among the 2,916 patients … Read more
A recent study published in Rheumatology (Oxford) revealed a significant association between elevated plasma interferon-alpha (IFN-α) protein levels during pregnancy and lower birth weight in infants born to women with systemic lupus erythematosus (SLE). The findings highlight a potential prognostic biomarker for adverse pregnancy outcomes in this high-risk population. The study followed 76 pregnant women … Read more
A recent Phase 3 randomized, double-blind study published in Seminars in Arthritis and Rheumatism evaluated the efficacy and safety of fasinumab, an investigational nerve growth factor (NGF) inhibitor, in patients with moderate-to-severe osteoarthritis (OA) pain of the knee or hip. The study compared fasinumab with placebo and nonsteroidal anti-inflammatory drugs (NSAIDs) over a 24-week period. … Read more
Xerostomia, or dry mouth, is a significant challenge for patients with Sjögren’s syndrome, often resulting in discomfort, difficulty in speaking and swallowing, and a reduced quality of life. A recent systematic review and meta-analysis, published in Current Therapeutic Research, provided new insights into the effectiveness of cevimeline in treating xerostomia in Sjögren’s syndrome. The study … Read more
A recent study published in Arthritis Research and Therapy has highlighted the emerging role of dipeptidyl peptidase-4 (DPP4) in ankylosing spondylitis (AS), revealing its potential as both a diagnostic biomarker and a therapeutic target. The study demonstrated that soluble DPP4 levels were significantly elevated in the serum and synovial fluid of AS patients, with increased … Read more
A pioneering study titled ESCORT-NGSK, recently published in Drug Discoveries & Therapeutics, provides critical insights into the real-world efficacy of switching from the etanercept reference product (RP) to its biosimilar in patients with rheumatoid arthritis (RA). The study, which incorporated both clinical indices and musculoskeletal ultrasound (MSUS) assessments, demonstrated that patients who transitioned to the … Read more
A recent study published in the International Journal of Nephrology and Renovascular Disease discovered significantly elevated levels of microRNA-203 in patients with lupus nephritis compared to those with systemic lupus erythematosus (SLE) without kidney involvement. This groundbreaking research highlights the potential of microRNA-203 as a diagnostic biomarker for lupus nephritis, offering new insights into its … Read more
A recent study published in the Journal of Clinical Medicine has uncovered important associations between antinuclear antibodies (ANA) and clinical outcomes in rheumatoid arthritis (RA) patients. The research, which analyzed data from 814 Japanese patients with RA, found that ANA positivity was observed in 41.5% of patients and was most commonly associated with speckled and … Read more
A large-scale population-based cohort study has revealed a concerning association between primary Sjögren’s syndrome (pSS) and an elevated risk of developing dementia. The research, published in The Korean Journal of Internal Medicine, analyzed data from the Health Insurance Review and Assessment database between 2008 and 2020, providing crucial findings into the long-term neurological risks faced … Read more