Researchers validate the role of serum biomarkers in determining disease activity of ANCA-associated vasculitis

A recent study published in Open Rheumatology has shown that the serum biomarkers CXCL3, IL6, IL8, IL5, IL8BP, matrix metalloproteinase-3, and ESR are associated with active disease in antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and IL15, IL8BP, and IL8 are found to be good at predicting flare. The former set of markers has shown a weaker … Read more

Named signs in Rheumatology

[presto_player id=1677]   How familiar are you with named signs in rheumatology? Some of the named signs in rheumatology include swan neck deformity in rheumatoid arthritis, sicca syndrome in Sjogren’s disease, Raynaud’s phenomenon in scleroderma, and Jaccoud’s arthropathy in SLE, Gottron papules in inflammatory myopathies, and Heberden’s nodes in osteoarthritis. Dr. Veena Ramachandran discussed named … Read more

Cells from a cheek swab may serve as biomarkers for female rheumatoid arthritis

In a recent study published in Scientific Reports, a group of researchers from Washington State University and Arthritis Northwest have suggested that epimutations in buccal and monocyte cells may serve as RA biomarkers in female patients. Genetics has been suggested to play a role in rheumatoid arthritis (RA) etiology. Several studies have reported gene associations … Read more

Eye and Rheumatology Series – Interactive session

Rheumatology and Ophthalmology interactive series Inflammatory disease of the eye- Introduction Ocular surface inflammation- introduction Dry eye conditions Episcleritis and scleritis Uveitis- type, assessment, and other ophthalmology description for physician and rheumatologist Anterior uveitis Posterior uveitis Panuveitis Orbital inflammation Tropical eye drops, periorbital and intraocular injections, and other local immune modulators Ophthalmology investigation and interpretations … Read more

Favorable benefit-risk ratio of upadacitinib compared to adalimumab for managing moderate-to severe RA

The findings of a post-hoc analysis conducted using the data from the SELECT-COMPARE trial have shown that the treatment using upadacitinib (UPA) has helped in achieving incremental clinical outcomes compared to adalimumab for managing moderate-to-severe RA. The benefit-risk assessment was carried out among a hypothetical cohort of 100 patients. The study has shown that UPA … Read more

Second COVID vaccine improves the serological response in patients with autoimmune diseases

A recent study by Simader et al., published in the Annals of Rheumatic Diseases, has concluded that full two-course immunization against SARS-CoV-2 is important to achieve efficient serological responses to vaccination in patients with rheumatoid arthritis (RA) and seronegative spondylarthritis (SpA) undergoing DMARD therapy. Vaccination has greater significance in reducing the morbidity of infectious diseases … Read more

Approach to Back pain -Physical Examination

Dr. Sayid Fahad Nizar discussed the approach to back pain and its physical examination. Local examination of the back is taken in two positions of the patients i.e., in standing and recumbent position. In the history-takingĀ of back pain, the spinal joints, costovertebral, and sacroiliac joints are mainly focused. The steps in the routine examination include … Read more