A small protein called CD24, which is glycosyl-phosphoinositol-anchored and sends T cells costimulatory signals, has been linked to the onset of autoimmune illness. According to a recent study published in the Annals of Medicine, soluble CD24 (sCD24) may serve as a biomarker of inflammation in patients with rheumatoid arthritis (RA), particularly in early and seronegative … Read more
A multidisciplinary strategy, comprising physical exercise therapy, occupational therapy, patient self-management, and pharmaceutical therapy, is necessary for the ideal care of rheumatoid arthritis (RA). According to a recent study published in Healthcare (Basel), the combination of occupational therapy and physical exercise improves the quality of life for rheumatoid arthritis (RA) patients. Cerasola and colleagues conducted … Read more
A significant public health concern revolves around the treatment of rheumatoid arthritis (RA), with patients and clinicians consistently seeking new approaches to alleviate the burden of this disease. In a recent study, researchers observed a favorable effect of pizza-related food items/groups on the more severe forms of RA. The cross-sectional study conducted by Dr. Roberta … Read more
The CC chemokine receptor 4 (CCR4) serves as a receptor for two chemokines: thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC). It has been identified as a valuable marker for Type 2 T helper (Th2) cells. According to a recent study published in Modern Rheumatology, elevated levels of CCR4 expression in peripheral blood samples … Read more
An altered T-cell subpopulation, elevated levels of inflammatory cytokines, and auto-antibodies are frequently present in rheumatoid arthritis (RA). Programmed cell death 5 (PDCD5) is an apoptosis-related gene cloned from TF-1 cells whose main biological roles are to induce apoptosis and immunological regulation. According to a recent study published in Rheumatology and Therapy, the incidence and remission … Read more
Patients with rheumatoid arthritis (RA) had worse quality sleep than healthy individuals and with age, achieving a decent quality of life following therapy becomes gradually more challenging. According to a study published in Journal of Rheumatic Diseases, improvement in sleep and quality of life was more in older RA patients after DMARDs therapy. Azizli and co-researchers … Read more
The weight-adjusted-waist Index (WWI), an innovative measure for assessing obesity, exhibits improved performance in estimating lean muscle and adipose tissue mass compared to both the body mass index (BMI) and waist circumference (WC). A recent finding published in BMC Musculoskeletal Disorders reveals that an increase in WWI is associated with a higher risk of osteoarthritis … Read more
Cardiovascular manifestations are prominent in rheumatoid arthritis (RA), and the majority of RA patients suffer from severe morbidity and death due to cardiovascular disease (CVD). A recent article published in Clinical Rheumatology investigated the potential association of elevated levels of galectin-3 with arterial stiffness and coronary microvascular dysfunction in RA patients. Galectin-3 is a β-galactoside–binding … Read more
In a randomized controlled trial published in JAMA Network Open, it was found that the effectiveness of tofacitinib is comparable to adalimumab for treating rheumatoid arthritis (RA). Both medications demonstrated clinically significant reductions in the mean disease activity score in 28 joints using C-reactive protein (DAS28-CRP) after three months of treatment, indicating a positive response … Read more