Rheuma Tv

A recent study published in Rheumatic and Musculoskeletal Diseases Open found that elevated baseline levels of complement activation marker C3dg and complement proteases MASP-1 and MASP-3 predicted new bone formation in axial spondyloarthritis (axSpA) patients after 2 years of TNF inhibitor therapy.   The complement system comprises more than 40 soluble and membrane-bound proteins that play a central role in innate immunity. … Read more

A new study published in The Lancet has found that nipocalimab, a neonatal Fc receptor (FcRn) blocker, significantly reduces clinical disease activity in patients with moderate to severe active Sjögren’s disease. The findings mark a major step forward for a condition that currently lacks approved targeted or disease-modifying therapies.  Nipocalimab acts by blocking FcRn, a … Read more

A new study published in Inflammopharmacology reports that L-carnitine, when administered alongside conventional disease-modifying antirheumatic drugs (DMARDs), may significantly improve clinical symptoms and reduce systemic inflammation in patients with active rheumatoid arthritis (RA). The findings suggest promising clinical benefits, although the supplement’s effects on key inflammatory signaling pathways remain unclear. In the randomized controlled trial, researchers enrolled 46 RA patients and … Read more

A new study published in Annals of the Rheumatic Diseases reports that patients with rheumatoid arthritis (RA) who receive Janus kinase inhibitors show a small but statistically significant increase in malignancy risk compared with those treated with biologic disease modifying antirheumatic drugs. The increased risk appeared particularly notable in certain patient groups and during longer … Read more

A recent study published in Current Rheumatology Reviews found that high dose omega 3 supplementation significantly improved fibromyalgia pain measures and was associated with increased serum magnesium and calcium levels. These findings align with preclinical evidence demonstrating multiple biological pathways through which omega 3 fatty acids exert analgesic effects. EPA and DHA modulate inflammatory responses by competing with arachidonic … Read more

A new analysis published in RMD Open reports that the neutrophil percentage to albumin ratio (NPAR) is significantly associated with increased osteoarthritis risk, with diagnostic performance in men comparable to that of C-reactive protein (CRP). The findings highlight the growing relevance of inflammatory composite markers in understanding musculoskeletal disease burden.  NPAR combines two widely available laboratory parameters: … Read more

A recent study published in Rheumatic and Musculoskeletal Diseases Open reported that nintedanib may help stabilize capillary density in patients with systemic sclerosis (SSc)-associated interstitial lung disease (ILD) who are at higher risk of disease progression. In contrast, placebo-treated high-risk patients demonstrated numerical reductions in capillary density over a 52-week period.  Nintedanib, an intracellular tyrosine kinase inhibitor, is an … Read more

Zasocitinib, an investigational oral tyrosine kinase 2 (TYK2) inhibitor, has demonstrated significant improvements in patients with active psoriatic arthritis, according to a recent study published in Annals of the Rheumatic Diseases. The findings highlight the potential of targeted oral therapies to address both joint and skin symptoms in immune-mediated inflammatory diseases.  TYK2, a Janus kinase–related enzyme, plays a … Read more

A recent study published in Seminars in Arthritis and Rheumatism found that postmenopausal women with rheumatoid arthritis (RA) who had lower cumulative lifetime estrogen exposure (CLEE) experienced more severe disease, poorer patient reported outcomes, and a reduced likelihood of achieving remission. The findings highlight the potential influence of hormonal history on disease progression and therapeutic response in women with … Read more