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Dr. Renuka discussed the different methods used to detect ANA and its application in the diagnosis of different diseases, and the patterns of ANA and ANA report guidelines were discussed. Newer techniques to detect ANA, Hep 2 pattern cells, prognosis & systemic sclerosis association with autoantibodies were discussed. IIF method is better than ELISA. ELISA test is not 100% sensitive when compared with IIF-ANA. Harmonization of the ANA assay reports helps the clinicians to understand the ANA testing reports.
Dr. Chandrashekara. S spoke about ANA detection, clinical relevance, and its interpretation. ANA is a good screening test for SLE. ANA sub-specificities guide a clinical syndrome. Positive ANA in suspected SLE should be further investigated for specificity. ANA positivity does not mean SLE.
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Good evening sir
Pt presents with multiple joints pain with fatigue .3 months
H/o fever and rashes . ANA POISITIVE ENA negative RF positive we treating for rheumatoid arthritis. .how frequen we have repeat ANA. IS THEY changes to over lap ctd after 2 3 years with treatment .
It depends on clinical scenario. if clinically consider as an infection induced auto-antibodies especially viral induced like CMV, EBV and other infection one can repeat the tests afte3 to 6 months. If its due to transient infection induced ANA it may disappear. In a well established CTD repetition of test is not recommended. The changing titer has not been shown to indicate the disease activity.
Excellent