Methotrexate- primer 1 by Rheuma Tv 18 Methotrexate- primer 1 1 / 5In the following conditions, the low dose of methotrexate is indicated except Psoriasis Malignancy Rheumatoid arthritis Juvenile Rheumatoid arthritis Methotrexate is used at low doses in conditions like psoriasis, rheumatic diseases, and anti-inflammatory disease. the low dose of methotrexate is 10-25 mg/week. In case of malignancies, methotrexate is given at higher doses above 500mg/week. For further details refer to Conventional DMARDS in Rheumatoid Arthritis, Lecture 4 Clinical use of Methotrexate in Rheumatology2 / 5What is the recommended dose of folic acid supplementation in methotrexate therapy? 10-30 mg/week 5-10 mg/week 60- 100 mg/week 120-150 mg/week The recommended dose of folic acid supplementation with methotrexate therapy is 5-10 mg/week. Dhir V et al. in their study on ‘Comparison of two different folic acid doses with methotrexate – a randomized controlled trial (FOLVARI Study)’ reported that Higher folic acid doses (>30mg/week) have not been shown to have any additional benefits or drawbacks over low doses (5–10 mg/week).1 Reference-Dhir V, Sandhu A, Kaur J, Pinto B, Kumar P, Kaur P, et al. Comparison of two different folic acid doses with methotrexate – a randomized controlled trial (FOLVARI Study). Arthritis Research & Therapy [Internet]. 2015 [cited 2022 Nov 3];17(1). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483203/3 / 5The following foods affect the action of methotrexate Milk Meat Berries Citrus fruits Explanation – When methotrexate is taken along with milk, the absorption of methotrexate is reduced, and the action of the methotrexate is affected. For further details refer to Lecture 3 Methotrexate:- Pharmacology, pharmacodynamics, and mechanism4 / 5What is the antidote used for methotrexate toxicity? Leucovorin Glucarpidase cholestyramine Both a & b Explanation – The commonly used antidotes used for methotrexate toxicity are leucovorin and glucarpidase. Leucovorin protects healthy cells from toxins that methotrexate’s suppression of decreased folates causes. Glucarpidase acts by removing methotrexate from the body. For further details refer to CS DMARDS in Rheumatoid Arthritis, Safety concern, precautions, and management of adverse events.5 / 5Methotrexate is not useful for treating the following inflammatory conditions Renal inflammation due to lupus nephritis Lung inflammation – ILD due to systemic sclerosis Axial inflammation- Spondylarthritis All the above Methotrexate is not used for treating renal inflammation due to lupus nephritis, Lung inflammation – ILD due to systemic sclerosis, and Axial inflammation- Spondylarthritis. For further details refer to Conventional DMARDS in Rheumatoid Arthritis, Lecture 4 Clinical use of Methotrexate in RheumatologyYour score is LinkedIn Facebook Twitter VKontakte How well-versed are you with methotrexate? Learn more by taking this little test.Share this:TwitterFacebookLinkedInPinterestWhatsAppMorePrintSimilar Posts
