This clinical lecture hosted by Rheuma TV features Dr. Chandrashekara S., Medical Director at ChanRe Rheumatology & Immunology Center & Research. The presentation explores second-line conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) used in the management of Rheumatoid Arthritis (RA). It covers the clinical pharmacology, mechanisms of action, efficacy profiles, dosage strategies, adverse effects, and laboratory monitoring protocols for less commonly prescribed or historical csDMARDs, including Azathioprine, Cyclosporine, D-penicillamine, and Gold salts.