Study highlights the need to improve cardiovascular preventive services in patients with rheumatoid arthritis

Rheumatoid arthritis (RA) is known to increase the risk of cardiovascular disease (CVD) regardless of traditional CVD risk factors, and the risk level is comparable to that of diabetes mellitus. According to a contemporary survey published in Rheumatic and Musculoskeletal Diseases Open, individuals with RA as their only CVD risk factor were less likely to undergo … Read more

High mobility group box 1 may serve as a new therapeutic target for rheumatoid arthritis

Inadequate management of rheumatoid arthritis (RA) can lead to joint deformity, loss of function, and a decline in the patient’s social engagement and quality of life. This, in turn, can impose a substantial economic burden on both the patient’s family and society. Therefore, it is crucial to develop new biomarkers and comprehensive approaches that can … Read more

Fourth COVID-19 vaccine dose significantly benefits autoimmune rheumatic disease patients

The increased risk of COVID-19 in patients with systemic autoimmune rheumatic diseases (SLE) is accentuated by the DMARD use, comorbidity burden, disease activity, and impaired immune responses. To address this concern, the U.S. Centers for Disease Control and Prevention recommends administering a fourth dose of the mRNA vaccine and the standard three-dose primary series for … Read more

Abnormalities in B cells and cytokines can indicate progressive erosive disease in RA

The goal of pharmacological treatment for rheumatoid arthritis (RA) is to achieve disease remission by preventing joint inflammation and progressive bone erosion. A recent study published in Frontiers in Immunology indicates that patients with progressive erosive disease exhibit abnormalities in B cells and cytokines that play a role in bone reabsorption.  The study, conducted by Marasco … Read more

Thyroid abnormality can be associated with rheumatoid arthritis severity

Rheumatoid Arthritis (RA) and autoimmune thyroid disease (AITD) are the two most prevalent coexisting autoimmune diseases due to their similar pathogenesis. A recent study published in the journal BMC Endocrine Disorder reported that among RA patients with more severe disease activity, thyroid dysfunction, anti-thyroid peroxidase (anti-TPO) antibody positivity, and AITD were considerably more prevalent.   … Read more

Increased bone morphogenetic protein receptor type 2 expression may enhance osteoblast differentiation in ankylosing spondylitis

BMPR2 is a transmembrane receptor that binds to signaling molecules called bone morphogenetic proteins (BMPs). It belongs to the TGF-beta receptor superfamily and is specifically involved in the regulation of bone morphogenesis. According to a recent article published in the Journal of Rheumatic Diseases, BMPR2 may play an integral role in the advancement of ankylosing … Read more

Serum bilirubin level may function as a promising biomarker of interstitial lung disease in primary Sjögren’s syndrome

According to a recent study published in BMC Pulmonary Medicine, serum bilirubin is independently linked to interstitial lung disease (ILD) and hence may act as a potential marker of ILD in primary Sjögren’s syndrome (pSS).  The retrospective analysis was carried out by Dr. Peng and colleagues on 89 consecutive patients who had been admitted to … Read more

Post-marketing safety study demonstrates the safety and efficacy of baricitinib in moderate-to-severe RA patients

The findings of a 24-week post-marketing safety study, recently published in Rheumatology and Therapy, reported that baricitinib was generally well tolerated in Chinese patients with moderate-to-severe active rheumatoid arthritis (RA), and its safety profile was consistent with previous studies. No new safety signals were identified. Additionally, the effectiveness of baricitinib was promising, with over half … Read more

D12 scores can serve as a reliable tool to measure dyspnea severity in patients with RA-ILD

dyspnea

According to a recent study published in the British Medical Journal Open Respiratory Research, D12 scores have reliable measuring qualities in RA-ILD. It enables the determination of the severity of dyspnea as described by its physical and affective components in patients with interstitial lung disease due to rheumatoid arthritis (RA-ILD).  Dr. Swigris and colleagues analyzed … Read more