[Day-1] Lecture Series 4 (Autoimmunity and Inflammation)

Dr. Sudheeran discussed the clinical perspective of neuroinflammatory diseases. Co-existence of other autoimmune diseases like vitiligo, signs of thyrotoxicosis/hypothyroidism, evidence of polyarthritis, rashes, orogenital ulcers, cachexia, and hyperpigmentation helps to identify autoimmune neurological diseases. In 60-70% of paraneoplastic encephalitis cases, paraneoplastic antibodies are the neuroimmunological markers.

The immunopathological mechanism of Neuroinflammatory Diseases was discussed by Dr. Girdhari Lal. Depressed people have increased levels of inflammatory cytokines (IL-6, TNF-α, IL-1β, and C-reactive protein. Psychological stress plays a crucial role in several autoimmune diseases including inflammatory bowel disease, psoriasis, rheumatoid arthritis, multiple sclerosis, diabetes, and chronic pulmonary sarcoidosis.

Thoihen Heikrujam discussed the immune mechanisms & inflammation in gastroenterology. Inflammatory diseases are caused by an immune response due to damage to the epithelial layer by various factors. Innate lymphoid cells (ILCs) and mucosa-associated invariant T cells (MAITs) are the important innate cells in maintaining gut homeostasis.

Watch this video to learn more about the immune mechanisms in neuroinflammatory diseases and garstroenterology.

 

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