In this clinical talk hosted on Rheuma TV, Dr. Raj Kiran (Consultant Rheumatologist, Hyderabad), along with Dr. Chandrashekara S., presents a comprehensive discussion on Tofacitinib, its clinical indications, and its practical application in rheumatology.The presentation covers key topics including:
Mechanism of Action: How targeted Janus Kinase (JAK) inhibition works to control intracellular inflammatory cytokine pathways.
Clinical Indications: Therapeutic use in Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Ankylosing Spondylitis (AS), and Juvenile Idiopathic Arthritis (JIA).
Dosage & Administration: Standard vs. extended-release dosing regimens and monotherapy vs. DMARD combination options.
Safety & Monitoring: Screening protocols (TB, Hepatitis B/C), infection risk management, lab monitoring, and patient selection considerations.