Dr. Sampath Rangasamy spoke about the role of inflammation in microvascular diabetic complications. Ang-2 is an important pro-inflammatory and provasopermeability agent in DR pathogenesis. CCL2 is a Pro-inflammatory cytokine mediating monocyte recruitment and microglial activation in DR pathogenesis.
Dr. Satinath Mukhopadhyay discussed fresh inflammatory tunes of metabolic disorder concern by Fetuin-A (Fet A). Fet A acts as an adaptor protein between FFA & TLR4 to promote adipose tissue inflammation and insulin resistance. Given that most anti-inflammatory approaches to prevent insulin resistance may carry the risk of unwanted inhibition of immune functions, more specific therapeutic approaches are of great interest.
Dr. Chandrashekara. S discussed immune metabolism being a potential area of intervention in inflammatory disease. An amendment to a bad program i.e., altering the metabolic pathways that are persistently active in inflammatory helps to achieve good control of inflammatory diseases.
Watch this video to learn more about the role of inflammation and immune metabolism.