Rheuma Tv

In a recent publication featured in Arthritis Research & Therapy, CXCL9 emerges as a pivotal biomarker for primary Sjögren’s syndrome (pSS), demonstrating remarkable efficacy in distinguishing between pSS patients with and without extra-glandular manifestations (EGM).  Hong and colleagues utilized advanced RNA sequencing techniques to analyze gene expression profiles in the minor salivary glands (MSG) of … Read more

Systemic inflammation appears to contribute to an increased risk of cardiovascular disease (CVD) in rheumatoid arthritis (RA) due to accelerated atherosclerosis. However, the impact of varying levels of disease activity over time on the progression of subclinical atherosclerosis (AP+) in patients with early RA (ERA) remains uncertain. A recent research article published in Rheumatic & … Read more

Anti-MDA5 antibody-positive dermatomyositis (MDA5+ DM), a specific subset within the spectrum of idiopathic inflammatory myopathies (IIM), demonstrates a significant association with rapidly progressive interstitial lung disease (RP-ILD). A recent study published in the Arthritis Research & Therapy elucidates the pivotal role of plasma secreted phosphoprotein 1 (SPP1) as an emerging prognostic biomarker for MDA5+ DM, … Read more

Study reveals IL1A as a significant risk factor for gout patients A study published in the recent issue of International Journal of Medical Sciences, establishes the critical role of the IL1A gene in the progression of gout, emphasizing its substantial diagnostic efficacy. Specifically, IL1A emerges as a key contributor to the exacerbation of inflammation associated … Read more

Fibromyalgia (FM) syndrome remains a distressing chronic pain condition marked by extensive suffering, mood swings, disrupted sleep, and persistent fatigue. In a recent publication in Open Access Rheumatology, findings emphasized the significance of deeper investigation into the connections among managed and unmanaged sleep disturbances, pain perception, somatization, and illness behavior in the health dynamics of … Read more

A recent study, featured in Arthritis Research and Therapy, has unveiled the crucial role of fructose-bisphosphatase1 (FBP1) in promoting polysaccharide synthesis within cartilage. This intricate process plays a pivotal role in reducing cartilage degeneration by modulating crumbs homolog 3 (CRB3). The study findings suggest that the targeted regulation of FBP1 holds promise as a potential … Read more

A recent study featured in Biochemical Pharmacology has revealed that the silencing of Gal-9 resulted in a significant reduction in the proliferation, migration, invasion, and expression of cytokines and matrix metalloproteinases (MMPs). Furthermore, this silencing induced apoptosis in tumor necrosis factor (TNF-α) induced RA-fibroblast-like synoviocytes (FLSs), primarily through the modulation of the musculoaponeurotic fibrosarcoma oncogene … Read more

Despite the approval of biological therapies like belimumab and anifrolumab for treating active systemic lupus erythematosus (SLE), there is a critical gap in the available treatments, with improved efficacy and safety. Addressing this need, a recently published phase 2 trial in the Annals of the Rheumatic Diseases sheds light on the promising efficacy and favorable … Read more

Systemic sclerosis (SSc) stands as a chronic immune-mediated disease with highest mortality rates among all rheumatic diseases. Prompt detection of SSc and the timely initiation of treatment play pivotal roles in achieving improved outcomes. A recent scientific nationwide population study underscores that elevated levels of gamma-glutamyl transferase (GGT) correlate with an increased risk of developing … Read more