Rheuma Tv

The triglyceride glucose index is a marker of insulin resistance and is considered a simple and cost-effective method for assessing metabolic health. A recent article in the European Review for Medical and Pharmacological Sciences highlights its potential correlation with psoriatic arthritis, suggesting its viability as a diagnostic tool for identifying psoriatic arthritis.  Tamer and colleagues … Read more

Osteoarthritis (OA) emerges as the third fastest-growing disability-linked disease, affecting over 500 million individuals worldwide. The latest research published in Arthritis Research and Therapy unveils the dual role of calcitonin gene-related peptide alpha (αCGRP) in mouse models, shedding light on inflammation and bone protection in primary OA.  Dr. Hildebrandt and team conducted the study involving female … Read more

A recent study published in Frontiers in Immunology has established a groundbreaking bidirectional relationship between thyroid function and the development of rheumatoid arthritis (RA). This two-sample Mendelian randomization (MR) study sheds light on the causative connection between hypothyroidism, hyperthyroidism, and RA, offering novel insights into their interconnectedness.  Gu et al. conducted the comprehensive two-sample bidirectional … Read more

Rheumatoid arthritis (RA) is a long-term autoimmune disease that causes inflammation. It is characterized by synovial hyperplasia. Maintaining an equilibrium between the growth and death of rheumatoid arthritis synovial fibroblasts (RASFs) is vital to prevent damage to bones and cartilage and ultimately slow down the progression of RA. A recent study published in Arthritis Research … Read more

Study  finds a strong connection between hyperuricemia and increased hand osteoarthritis risk  The etiology of hand osteoarthritis (OA) is largely elusive, demanding further research to understand its causes and guide the development of preventive and treatment approaches. Past research has highlighted the role of hyperuricemia  in triggering the pro-inflammatory reaction, potentially influencing the development of … Read more

Bruton’s tyrosine kinase (BTK) inhibition is a novel pharmaceutical strategy under active investigation for treating inflammatory, allergy, and autoimmune diseases. Remibrutinib, an oral, covalent, highly selective, and potent BTK inhibitor, has shown significant pathway inhibition in human studies, demonstrating a favorable safety profile across the entire dose range. A recent randomized, double-blind, placebo-controlled phase 2 … Read more

Serum metabolites can serve as a diagnostic tool for systemic lupus erythematosus  According to a recent study published in Frontiers in Molecular Biosciences, certain metabolites were found to play a dual role by acting as intermediaries in the genesis and progression of systemic lupus erythematosus (SLE) or serve as factors in the immune response that … Read more

According to a recent study published in Arthritis Research and Therapy, individuals with rheumatoid arthritis (RA) may have their response to sarilumab predicted by single-nucleotide polymorphisms (SNPs) in the IL6R gene, as well as anticipate potential adverse reactions.  Conducted by Sainz and colleagues, the retrospective cohort study involved 62 patients treated with sarilumab. The primary … Read more

Upadacitinib is a Janus kinase (JAK) inhibitor proven to be an effective treatment for adults with rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), non-radiographic axial spondyloarthritis, and ulcerative colitis. Additionally, it has demonstrated effectiveness in treating both adults and adolescents with atopic dermatitis.  According to a recent study published in Rheumatic and Musculoskeletal … Read more