Rheuma Tv

A recent study published in Arthritis Research & Therapy has highlighted a compelling association between gut inflammation and structural spinal damage in patients with axial spondyloarthritis (axSpA), independent of other established risk factors for radiographic progression.  While genetic, immune, and environmental factors are known contributors to the disease pathogenesis, emerging evidence indicates that intestinal inflammation and alterations in gut microbiota … Read more

A recent groundbreaking study has highlighted the potential of a novel interferon gamma release assay as a powerful biomarker for assessing disease activity and predicting treatment response in patients with systemic lupus erythematosus (SLE).  Cytokines are key mediators of immune regulation, and their role in autoimmune diseases such as SLE is well recognized. In lupus, the overproduction … Read more

More than half of patients with primary Sjögren’s syndrome (pSS) experience depression and anxiety, shedding light on the role of inflammation in neuropsychiatric symptoms associated with chronic autoimmune diseases. Evidence from both animal and clinical studies indicates that elevated levels of the cytokine interleukin 6 (IL 6), whether in the peripheral circulation or central nervous system, play … Read more

In a first of its kind investigation using MRI based muscle assessment, researchers have reported that tofacitinib, a Janus kinase (JAK) inhibitor used in rheumatoid arthritis (RA), may promote muscle growth alongside its anti-inflammatory benefits.  The recent study published in The Lancet Rheumatology revealed that patients with RA treated with tofacitinib experienced significant gains in lower limb … Read more

A recent study published in Reumatología Clínica has found that rheumatoid arthritis (RA) patients with rotator cuff tendinopathy exhibit significantly higher disease activity compared to those without this concurrent shoulder condition.  The cross-sectional, observational study included RA patients with shoulder pain who met the 2010 ACR-EULAR classification criteria between January 2022 and January 2023. The … Read more

Avacopan is a small-molecule complement 5a receptor (C5aR or CD88) antagonist approved by the United States Food and Drug Administration as an adjunctive therapy in combination with immunosuppressants and corticosteroids for the treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. By selectively inhibiting the C5a receptor, avacopan blocks neutrophil chemoattraction, activation, and adhesion while preserving other … Read more

A recent study published in BMJ Open has revealed that the fat-to-muscle ratio (FMR) is significantly associated with secondary osteoporosis (OP) in patients with rheumatoid arthritis (RA). The study enrolled 670 hospitalized RA patients and 126 healthy controls at a tertiary hospital in eastern China between October 2019 and October 2022.  Analysis indicated that RA patients had … Read more

Antibodies directed against the Ro/SS-A system, traditionally linked with autoimmune diseases such as systemic lupus erythematosus and Sjögren’s syndrome, are now gaining attention for their role in systemic sclerosis (SSc). This system comprises two distinct target proteins with unique biochemical and immunological functions and includes Ro60 (60 kDa) and Ro52 (52 kDa). Ro52, also known … Read more

A recent study published in Clinical and Experimental Rheumatology has identified soluble triggering receptor expressed on myeloid cells 2 (sTREM2) as a promising biomarker for predicting the development of neuropsychiatric systemic lupus erythematosus (NPSLE). Researchers also developed a novel nomogram incorporating this biomarker to aid clinical prediction.  The study, which enrolled 80 patients with NPSLE … Read more