A cornerstone conventional synthetic Disease-Modifying Antirheumatic Drug (csDMARD) used in rheumatology. The video covers its core pharmacology and pharmacodynamics, detailing its lysosomotropic mechanism of action—including intra-lysosomal pH alteration, suppression of antigen presentation, Toll-like receptor (TLR) inhibition, and cytokine modulation. Additionally, it highlights its therapeutic roles in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), pharmacokinetic profiles, dosage guidelines, and essential clinical safety monitoring such as screening for retinal toxicity.
